Antidepressive Action of UrocortinsPossible Therapeutical Application

来源 :2008中国深圳蛋白质和多肽科学大会 | 被引量 : 0次 | 上传用户：d34276

【摘要】

：

　　Urocortins (Urocortin 1,2 and 3) are member of the corticotropin releasing homone (CRH) family.Two receptors have been isolated CRHR-1 and CRHR-2.CRH is bou

【作者】

：

Gyula Telegdy Masaru Tanaka

【机构】

：

MedicalSchoolUniversityofSzegedHungary

【出处】

：

2008中国深圳蛋白质和多肽科学大会

【发表日期】

：

2008年4期

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　　Urocortins (Urocortin 1,2 and 3) are member of the corticotropin releasing homone (CRH) family.Two receptors have been isolated CRHR-1 and CRHR-2.CRH is bound to CRHR-I receptor,while urocortin 1 binds to CRHR-1 and CRHR-2.urocorfin 2 binds prefarably to the CRHR-2 receptor and urocortin-3 binds exclusively to the CRHR-2 receptor.Urocortins (Urocortin 1,2 and 3) have been tested in a modified swimming test in mice for detection of anti-depressant effects.The test involved scoring the immobility,climbing and swimming behavior of mice in a modified forced swimming behavior (FST).Urocortin 1 had no action on any of the parameters studied in the modified FST.

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Antidepressive Action of UrocortinsPossible Therapeutical Application

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