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Background: Interferon-γ (IFN-γ) and Signal transducers and activators of transcription (STATs) each play an important role in carcinogenesis associated with viral infection.Cervical cancer is almost invariably associated with infection by human papillomavirus (HPV),and previous studies suggest an association between IFN-γ and STATs and cervical cancer risk.Methods: We evaluated the association between cervical cancer risk and single-nucleotide polymorphisms (SNPs) in the STAT2,STAT3,and IFN-γgenes in 234 cases and 216 matched population-based controls in Chinese Han women in Hunan province.Results: Our results suggest that for STAT2 rs2066807,STAT3 rs957970 and IFN-γ +874A/T polymorphisms,there was no significant difference in genotype distribution and allele frequencies between cases and controls.Conclusions: Polymorphisms in STAT2,STAT3 and IFN-γ genes are not likely to be strong predictors of cervical cancer in Han women in southern China.