【摘 要】
：
Nodal ratio (NR) is defined as the absolute number of involved nodes to the number of nodes examined.Since me 1990s, a few researchers suggested that it provides greater prognostic value than absolute
【机 构】
：
Department of Radiation Oncology Allan Blair Cancer Center University of Saskatchewan Regina, SK Can
【出 处】
：
BIT‘s2nd Annual World Cancer Congess-2009 (2009第二届癌症大会)
论文部分内容阅读
Nodal ratio (NR) is defined as the absolute number of involved nodes to the number of nodes examined.Since me 1990s, a few researchers suggested that it provides greater prognostic value than absolute number of involved nodes in breast cancer management.Previous reports in breast cancer have generally analyzed patients with 1-3 positive lymph nodes as a single group often leading to controversy in practical clinical applicability.This study separately analyzed the survival outcomes among T1-2 breast cancer patients based on whether 1 or 2 axillary nodes were pathologically positive.Records of 5,996 patients were available for analysis from the population-based Canadian Saskatchewan provincial registry for the period from 1981 through 1995.Since the reliability of nodal assessment depends on the number of nodes sampled, only those 613 patients staged as T1-2, with 8 nodes examined were further analyzed for overall (OS) and cause-specific survival (CSS).There were 378 patients with 1 involved node, with NR range of 0.03-0.13.Among 235 patients with 2 involved nodes, 110 had a NR of-3d 0.15 and the remaining 125 patients have a NR of 0.16-0.25.We found that patients with 1 and 2 positive nodes had similar survival.The OS of the 613 patients with 1 and 2 nodes at 5-years were 83%, 77%; at 10-years: 65%, 61%; at 15-years: 49%, 48%, respectively (P=0.34).CSS rates at 5-years were 89%, 82%; at 10-years: 79%, 73%; at 15-years: 73%, 69%, respectively (P=0.12).However, the OS of the patients with nodal ratio of-3d 0.15 versus 0.16-0.25 at 5-years were 82%, 74%; at 10-years: 65%, 58%; at 15-years: 50.0%, 45%, respectively (P=0.11).CSS rates at 5-years were 89%, 77%; at 10-years: 79%, 69%; at 15-years: 73%, 64%, respectively (P=0.01).Hence CSS was significantly different using NR as a prognosticator.In conclusion, NR is superior to absolute number of nodes in our current staging to separate patients with 1 or 2 positive nodes.The survival data among patients with 1-2 nodes positive reveals clearly relevant differences when separately analyzed.This may affect adjuvant treatment decision-making.
其他文献
B-cell receptor (BCR) signaling plays an important role in the pathogenesis of chronic lymphocytic leukemia (CLL).We tested whether blocking BCR signaling with dasatinib, an inhibitor of SRC kinase, w
Estrogens, especially 17β-estradiol or E2, a biologically potent estrogen, play very important roles in the proliferation and development of hormone dependent breast carcinoma cells and some of these
Maximal and sustained activation of T lymphocytes requires integration of the signaling pathways downstream of the TCR (T Cell Receptor) and of coreceptors such as CD28.Upon T cell activation, TCR sig
In renal cell carcinoma (RCC), HKLA class Ⅰ down regulation has been found in 40% of the tumor lesions examined.Since only scanty information is available regarding the molecular basis of these defect
Treatment of cancer has been dominated by the triad surgery, radiotherapy, chemotherapy, three methods that become palliative when the tumors metastasize.Cancer cells are viewed as having acquired pro
Interleukin 10 (IL-10) is produced by various types of human cancer, including malignant melanoma, and plays an important role in negative regulation of cell-mediated immune responses against tumors.W
Cutaneous T-cell lymphomas (CTCL) are disfiguring cancers of white blood cells called T-cells that first appear as skin lesions or tumors.CTCLs are incurable at present and treatments such as chemothe
Antigen targeted immunotherapies might represent a novel treatment for B-cell chronic lymphocytic leukemia (CLL).Differential expression of molecules in CLL might define both prognostic markers and su
Current chemotherapeutic treatment of acute myeloid leukemia (AML) patients is effective in terms of remission rates (70%-80%).However, half of these remission patients experience recurrence of diseas
The object of this study was to understand why breast cancer frequently occurs in the left breast among both women and men.Moreover, recent results showed that the left side of the body also is more p