泡沫病毒(foamy virus,FV)属于反转录病毒科泡沫病毒亚科,它在体外培养的细胞或组织中能引起强烈病变效应,但尚未有报道表明它能在天然宿主体内形成致病症状,仅潜伏感染并伴随宿主终身。原型泡沫病毒(prototypefoamy virus,PFV)作为唯一感染人类的泡沫病毒,已经发现数种宿主限制因子可以抑制PFV复制,但PFV感染对细胞基因表达的影响尚待全面深入研究。本实验室前期利用PFV感
Ganoderma lucidum is a rare Chinese traditional medicine which is beneficial to the mind and body,prolonging life used by Chinese medicine.Our previous study found that Ganoderma lucidum miR-01 entere
侵袭转移是恶性肿瘤的最重要的生物学特征。肿瘤细胞的旺盛生长使其对铁需求远大于正常细胞，所以螯合治疗成为一种重要治疗策略。铁螯合剂展示了良好抗肿瘤特性及抑制侵袭转移能力，但作用机理尚未充分阐明。二硫代甲酸衍生物是一类重要的铁螯合剂，能从铁蛋白中萃取铁。细胞增殖评估显示它对HepG2、HCT-116、CT26细胞的生长有较强的抑制作用；克隆形成实验获得相似结果；Balb/c小鼠移植瘤实验表明二硫代甲酸
Tumor chemo-and radiotherapy induces hematopoietic organ damage and reduces thrombocyte counts.Conventional platelet transfusion strategies or drug therapies are used to treat thrombocytopenia.However
MET overactivation is one of crucial bypass resistance mechanism in EGFR-mutant NSCLC patients.But the regulation mechanisms of MET are not wholly clear,it is necessary to further explore more informa
p21WAF1/CIP1 is a broad-acting cyclin-dependent kinase inhibitor.Its stability is essential for proper cell cycle progression and cell fate decision.Ubiquitylation by the multiple E3 ubiquitin ligases
The proteolysis-assisted protein quality control system guards the proteome from potentially detrimental aberrant proteins.How miscellaneous defective proteins are specifically eliminated and which mo
Wnt/β-catenin信号通路在早期神经发育中起主要作用。当其紊乱会导致神经前-后轴发育缺陷引发神经管闭合缺陷(NTDs)。叶酸代谢的变化可能参与由转录因子驱动的早期胚胎命运决定。本研究发现神经管缺陷(NTDs)的低叶酸标本中，绒毛膜特异性转录因子Gcm1在标本脑组织中表达上调，并与β-catenin蛋白相互结合。
It has been established that the elimination of Geomagnetic field(GMF),so called the Hypomagnetic field(HMF),has adverse effects on the development,physiology and behaviors of animals.A few studies ha
Chemotherapy is a main category of cancer treatment that aims to prolong life or to reduce symptoms.Besides blocking cell proliferation,most chemotherapeutic agents used clinically cause DNA lesions t