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BACKGROUND: Alzheimers disease is an age-related neurodegenerative disorder, and the underlying mechanisms remain poorly understood.Emerging data has been proposed that mitochondrial dysfunction is one of prominent causes of Alzheimers disease (AD) progress.Sirtuin-3 (Sirt3) is a member of sirtuins family of nicotinamide adenine dinucleotide (NAD+) dependent deacetylases, the main mitochondrial lysine deacetylase which regulated a variety of mitochondrial functions and suppressed mitochondrial related physiology in the context of deficiency sirt3.This study aimed to confirm the expression of sirt3 and likely association with sirt3 and mitochondrial dysfunction in AD.