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应用抗人胎盘型谷胱甘肽Ｓ－转移酶（ＧＳＴ－π）单克隆抗体，以微波ＬＳＡＢ免疫组化技术，检测了ＧＳＴ－π在人乳腺癌中的表达情况。１３２例乳腺癌中，７８．，８％（１０４／１３２）呈阳性表达。ＧＳＴ－π表达与患者年龄、肿瘤大小及腋窝淋巴结转移无明显相关，与组织学类型有一定关系，ＧＳＴ－π在ＥＲ（一）乳腺癌的阳性表达率９１．３％，显著高于ＥＲ（＋）者６４．４％（Ｐ＜０．０１），同样ＧＳＴ－π在ＰＲ（一）乳腺癌的阳性率８８．２％，也显著高于ＰＲ（＋）者６６．７％（Ｐ＜０．０５）。结果表明，ＧＳＴ－π的表达与乳腺癌发生、发展的关系密切，且与ＥＲ和ＰＲ的表达呈明显负相关，文中就其临床意义进行了讨论。
The anti-human placental glutathione S-transferase (GST-π) monoclonal antibody was used to detect the expression of GST-π in human breast cancer by LSAB immunohistochemistry. 132 cases of breast cancer, 78. , 8% (104/132) positive. The expression of GST-πwas not related with age, tumor size and axillary lymph node metastasis, but also with histological type. The positive rate of GST-π in ER (1) breast cancer was 91.3%, which was significantly higher than that in ER +) Were 64.4% (P <0.01). Similarly, the positive rate of GST-π in PR (1) breast cancer was 88.2% and significantly higher than that in PR (+) 66.7% 0.05). The results showed that the expression of GST-π was closely related to the occurrence and development of breast cancer, and was negatively correlated with the expression of ER and PR. The clinical significance of GST-π was discussed.