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目的研究中心性浆液性脉络膜视网膜病变(CSC)患者频域光学相干断层成像(SD-OCT)图像中椭圆体带、锥体外节尖端(COST)层变化与其病程、最佳矫正视力(BCVA)的相关性。方法对CSC患者(A组,24例)和正常志愿者(C组,24例)进行SD-OCT检查,分析CSC患眼椭圆体带、COST层的形态特征与BCVA、病程的关系。结果 A组BCVA低于C组(0.60±0.21vs.1.20±0.18)(t=9.632,P<0.01)。A组16例患者为COST层保存完好型,8例患者为COST层保存不全型,BCVA分别为0.80±0.12和0.50±0.22,比较差异有统计学意义(t=5.295,P<0.05);18例患者为椭圆体带连续完整型,6例患者为不完整(断裂)型,BCVA分别为0.80±0.16和0.40±0.13,比较差异亦有统计学意义(t=6.138,P<0.05)。CSC病程与BCVA呈负相关(r=-0.847,P<0.01)。结论 CSC患者BCVA与光感受器椭圆体带、COST层形态密切相关。光感受器的精细观察对CSC患者视力预后、病程评估有一定指导意义。
Objective To study the change of elliptic zone and apical end point (COST) in patients with central serous chorioretinopathy (CSC) and its course of disease, best corrected visual acuity (BCVA) Correlation. Methods SD-OCT was performed in CSC patients (group A, n = 24) and normal volunteers (group C, n = 24), and the relationship between morphological features and BCVA and duration of CSE eyes was analyzed. Results The BCVA of group A was lower than that of group C (0.60 ± 0.21 vs.1.20 ± 0.18) (t = 9.632, P <0.01). In group A, 16 patients were well preserved in COST layer, 8 patients were preserved in COST layer, with BCVA of 0.80 ± 0.12 and 0.50 ± 0.22, respectively, with significant difference (t = 5.295, P <0.05); 18 The patients were continuous with an intact ellipsoid, and 6 patients were incomplete. The BCVA was 0.80 ± 0.16 and 0.40 ± 0.13, respectively, with statistical significance (t = 6.138, P <0.05). The course of CSC was negatively correlated with BCVA (r = -0.847, P <0.01). Conclusions BCVA in CSC patients is closely related to the photoreceptors ellipsoid zone and COST layer. Photoreceptors fine observation of CSC patients with visual acuity, disease course evaluation has some guiding significance.