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Recently, we gave a new perspective of Web Intelligence (WI) research from the viewpoint of Brain Informatics (BI), a new interdisciplinary field that studies the mechanisms of human information processing from both the macro and micro viewpoints by combining experimental cognitive neuroscience with advanced information technology. We argue that new instruments like fMRI and information technology will revolutionize both Web intelligence and brain science. This revolution will be bi-directional: new understanding of human intelligence through brain science will yield a new generation of Web intelligence research and development, and Web intelligence portal techniques will provide a powerful new platform for brain science. The ultimate goal is to establish the foundation of WI towards human-level Web intelligence. In this talk, we investigate how to make such a study successfully.