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目的观察孟鲁司特联合布地奈德治疗过敏性鼻炎-哮喘综合征的疗效。方法治疗组口服孟鲁司特10mg,1次/d;同时吸入布地奈德气雾剂400μg,2次/d。对照组吸入布地奈德气雾剂400μg,2次/d,共治疗12周。观察了两组肺功能和气道反应性。结果两组均可显著肺通气功能,降低气道高反应性,治疗前后差异有统计学意义(P<0.01),治疗组降低气道高反应性方面对照组,差异有统计学意义(P<0.01)。结论对过敏性鼻炎-哮喘综合征患者联用孟鲁司特与布地奈德的效果,优于单用布地奈德。
Objective To observe the efficacy of montelukast combined with budesonide in the treatment of allergic rhinitis - asthma syndrome. Methods The treatment group was treated with montelukast 10 mg once daily and inhalation of budesonide aerosol 400 μg twice daily. The control group inhaled budesonide aerosol 400μg, 2 times / d, a total of 12 weeks. Two groups of lung function and airway responsiveness were observed. Results Both groups had significant pulmonary ventilation and decreased airway hyperresponsiveness (P <0.01), while the control group in the treatment group had lower airway hyperresponsiveness, the difference was statistically significant (P < 0.01). Conclusions The effect of combined use of montelukast and budesonide in patients with allergic rhinitis-asthma syndrome is better than that of budesonide alone.