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头颈部鳞癌的传统疗法是手术切除和放射治疗。其他疗法包括冷冻手术或对新生物加热到接近致死温度(42～43℃)。现在又提出了对于实质性肿瘤的多种药物疗法,重新引起人们对运用这一方法的重视。Overgaard(1976)发现如果同时对肿瘤加热到43℃,阿霉素和争光霉素的杀瘤效力可大大加强。Hahn和Benjaman(1979)已证明,加热和放射联合治疗表浅部癌,有效率为76%,而单独用放射治疗的对照组,有效率仅为26%。作者报告了22例头颈部不同部位的癌(以鳞癌为主),用阿霉素和争光霉素配合发热治疗,取得了较好效果。根据病人曾否接受过放射治疗,分为两组:(1)放射治疗后组:化疗加发热治疗(简称R-CT组)。(2)综合治疗组:放
The traditional treatment for head and neck squamous cell carcinoma is surgical resection and radiation therapy. Other therapies include cryosurgery or heating of new organisms to near lethal temperatures (42-43°C). Now a number of drug therapies for substantial tumors have been proposed, reviving the importance of applying this method. Overgaard (1976) found that if tumors were heated to 43°C at the same time, the killing effect of doxorubicin and bleomycin could be greatly enhanced. Hahn and Benjaman (1979) have demonstrated that the combination of heat and radiation for the treatment of superficial cancer has an effective rate of 76%, whereas the control group treated with radiation alone has an effective rate of only 26%. The authors reported 22 cases of cancers of different parts of the head and neck (mainly squamous cell carcinoma), and treated with doxorubicin and oxytocin with fever, and achieved good results. According to whether the patient had received radiation therapy, they were divided into two groups: (1) After radiation therapy group: chemotherapy plus fever therapy (referred to as R-CT group). (2) Comprehensive treatment group: release