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目的和方法：观察Binswanger病患者血清肿瘤坏死因子-α的变化。Binswanger病组对例，多发性梗塞性痴呆组16冽，健康对照组6例。应用放射免疫法测定血清及胞脊液中肿瘤坏死因子-α含量，用预内静脉与肘静脉血清肿瘤坏死因子-α含量的比值反映脑循环中肿瘤坏死因子-α的水平。结果：Binswanger病组脑循环及脑脊液中肿瘤坏死因子-α显著高于其它两组，两个指标均与Binswanger病患者简易智力状态量表积分呈负相关。结论：肿瘤坏死因子-α可能参与了Binswanger病的发病机制。
Objective and Methods: To observe the changes of serum tumor necrosis factor-α in patients with Binswanger’s disease. Binswanger disease group of cases, 16 cases of multiple infarct dementia group, 6 cases of healthy control group. The level of tumor necrosis factor-α in serum and CSF was measured by radioimmunoassay, and the ratio of tumor necrosis factor-α in pre-vein and elbow vein was used to reflect the level of tumor necrosis factor-α in the brain. Results: The levels of TNF-α in cerebral circulation and cerebrospinal fluid in Binswanger’s disease group were significantly higher than those in the other two groups, and both of them were negatively correlated with the score of simple mental state in Binswanger’s disease group. Conclusion: Tumor necrosis factor-α may be involved in the pathogenesis of Binswanger’s disease.