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本文检测了５２例原发性肝细胞癌（ＰＨＣ）患者的干扰素γ（ＩＦＮ）、细胞毒因子（ＭＣＣＦ）和肿瘤坏死因子（ＴＮＦ）活性的变化，另将３２例肝炎性肝硬化（ＬＣ）作为对照。结果表明，上述患者的外周血单个核细胞（ＰＢＭＣ）产生ＩＦＮ活性降低，以ＰＨＣ患者的改变更为明显。ＰＨＣ的ＭＣＣＦ及ＴＮＦ活性均高于正常人。提示宿主机体ＩＦＮ活性低下，削弱了机体抗病毒和抗肿瘤免疫活性，可导致ＰＨＣ发生和发展。如能合理应用ＩＦＮ和ＴＮＦ等细胞因子治疗ＰＨＣ，可能取得治疗ＰＨＣ的较好疗效。
This study examined the changes in interferon gamma (IFN), cytotoxicity factor (MCCF), and tumor necrosis factor (TNF) activity in 52 patients with primary hepatocellular carcinoma (PHC), and another 32 patients with hepatic cirrhosis (LC). )as comparison. The results showed that the peripheral blood mononuclear cells (PBMCs) produced by these patients had decreased IFN activity, which was more pronounced in patients with PHC. The activity of MCCF and TNF in PHC was higher than normal. It suggests that the host IFN activity is low, weakening the body’s antiviral and anti-tumor immune activity, which can lead to the occurrence and development of PHC. If we can reasonably use cytokines such as IFN and TNF to treat PHC, we may obtain better results in the treatment of PHC.