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移植物抗宿主病(GVHD)是同种异基因骨髓移植成功的主要障碍。目前普遍认为移植物中成熟T淋巴细胞介导急性和慢性GVHD。因而近年来运用多种方法去除或抑制T淋巴细胞显著地降低了GVHD的发病率。但这些处理延缓了移植后受者的免疫功
Graft-versus-host disease (GVHD) is a major obstacle to successful allogeneic bone marrow transplantation. It is now generally accepted that mature T lymphocytes in the graft mediate acute and chronic GVHD. Thus in recent years the use of various methods to remove or inhibit T lymphocytes significantly reduces the incidence of GVHD. However, these treatments delayed the immune function of recipients after transplantation