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本文运用病例对照研究方法,应用免疫酶法检测了126例鼻咽癌病例与对照者家族内1328名一级亲属血清中的 EB 病毒 VCA 抗体。结果发现 VCA-IgA 在鼻咽癌病例家族内似具聚集现象,鼻咽癌病例一级亲属组 IgA 阳性率(7.75%)显著高于对照组(4.41%)。表明 EB 病毒与鼻咽癌关系极为密切,同时也提示应鼻咽癌病例家族成员考虑为鼻咽癌普查与防治中的重点高危人群。本文还对鼻咽癌病例家族成员是否对 EB 病毒具有较高的遗传易感性进行了初步讨论。
In this study, case-control study was used to detect the EBV VCA antibody in serum of 126 cases of nasopharyngeal carcinoma and 1328 first-degree relatives in control family. The results showed that VCA-IgA appeared to be clustered in the nasopharyngeal carcinoma family. The positive rate of IgA in the first-degree relatives of patients with nasopharyngeal carcinoma (7.75%) was significantly higher than that in the control group (4.41%). It shows that the relationship between EB virus and nasopharyngeal carcinoma is very close, and it also suggests that nasopharyngeal cancer family members should be considered as the key high-risk group in the survey and prevention of nasopharyngeal carcinoma. This article also discusses whether the family members of nasopharyngeal carcinoma have a high genetic susceptibility to EB virus.