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二磷酸腺苷核糖转移酶(ADPRT)催化辅酶I(NAD)分子上的ADP-核糖组分转移到蛋白质或另一个ADP-核糖分子上形成多聚体(ADP-R)_n。这一过程与细胞的多种生物学功能有关。近年来国外一些研究报道该酶的抑制剂在抑制DNA修复的同时还能加强某些抗癌药物如链脲霉素、博莱霉素、亚硝脲类化合物和顺铂的抗癌作用,引起人们的关注,为发展高效低毒的化疗途径提供了新的希望。我们曾在体外实验证明ADPRT抑制剂3MB
ADP-ribose dismutase (ADPRT) catalyzes the transfer of the ADP-ribose moiety on the coenzyme I (NAD) molecule to a protein or another ADP-ribose molecule to form a polymer (ADP-R)_n. This process is related to the various biological functions of cells. In recent years, some foreign studies have reported that inhibitors of this enzyme can inhibit DNA repair and at the same time strengthen the anti-cancer effects of certain anti-cancer drugs such as streptozotocin, bleomycin, nitrosoureas, and cisplatin. People’s attention has provided new hope for the development of highly effective and low-toxic chemotherapy. We have demonstrated in vitro 3x ADPRT inhibitor