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荚膜抗原、鼠毒素和内毒素是鼠疫杆菌细胞的主要组成部份,并与细菌的致病力有关。本文介绍上述抗原的结构、功能和生物学特性。一、荚膜抗原鼠疫杆菌无论在体内或体外增殖,菌体表面均能形成荚膜抗原,纯化的荚膜抗原命名为F1。早在四十年代,Baker等用20～40%饱和硫酸铵沉淀和用水抽提取得了多糖-蛋白质复合物和蛋白质,分别标志为Fl_A和l_B。Chen等(1977)经电镜观察,荚膜抗原在菌体表面形成颗粒层,并能向周围扩散。Волотареву(1983)指出,荚膜抗原不仅位
The capsular antigens, toxins and endotoxins are the major components of Yersinia pestis cells and are associated with the pathogenicity of bacteria. This article describes the structure, function and biological properties of the above antigens. First, the capsular antigen Yersinia pestis in vivo or in vitro proliferation, cell surface can form a capsular antigen, purified capsular antigen named F1. As early as the forties, Baker and his colleagues used 20-40% saturated ammonium sulphate to precipitate and extract polysaccharides-protein complexes and proteins, labeled as Fl_A and l_B, respectively. Chen et al. (1977) observed by electron microscopy, capsular antigens in the cell surface layer of particles, and can spread to the surrounding. Волотареву (1983) pointed out that not only capsid antigen