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目的:评价中西医结合治疗强直性脊柱炎的临床疗效。方法:计算机全面检索PubMed(1990～2012)、中国知识期刊网(1979～2012)、维普中文科技期刊数据库(1989～2012)、万方数据库收录(1998～2012),中国生物医学文献服务(1979～2012)收集单用西药与中西医结合治疗强直性脊柱炎的随机对照研究,并辅以手工检索。对纳入研究的质量进行评价,用RevMan5.0软件进行Meta分析,包括异质性检验、合并效应量、评估发表偏倚以及敏感性分析。结果:共收集到相关文献188篇,其中符合纳入标准的有6篇;6项研究总有效率合并OR值为4.42[95%CI(2.72,7.17)]。结论:中西医结合较单纯西医治疗强直性脊柱炎有更好的疗效。但由于纳入试验文献的质量不高,待纳入更高质量的文献作进一步研究。
Objective: To evaluate the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of ankylosing spondylitis. Methods: We searched PubMed (1990 ~ 2012), Chinese Knowledge Periodical Network (1979 ~ 2012), VIP Chinese Science and Technology Periodical Database (1989 ~ 2012), Wanfang Database (1998 ~ 2012), Chinese Biomedical Literature Service (1979) ~ 2012) collected a single Western medicine and integrated traditional Chinese and Western medicine treatment of ankylosing spondylitis randomized controlled study, supplemented by manual retrieval. The quality of the included studies was evaluated, and Meta-analysis was performed using RevMan 5.0 software, including heterogeneity tests, combined effect amounts, publication bias assessments, and sensitivity analyzes. Results: A total of 188 articles were collected, of which 6 met the inclusion criteria. The total combined OR of the 6 studies was 4.42 [95% CI (2.72,7.17)]. Conclusion: Integrative Medicine than Western medicine treatment of ankylosing spondylitis has a better effect. However, due to the poor quality of the included trials, further research into higher quality literature is needed.