论文部分内容阅读
目的不明原因复发流产患者主动免疫治疗的效果及对Treg/Th17免疫平衡的影响。方法选取郑州市妇幼保健院2013年5月至2015年5月收治的70例不明原因复发流产患者为研究对象,根据是否接受主动免疫治疗分为治疗组(50例)与对照组(20例),治疗组给予主动免疫治疗,对照组由于各种原因不同意采取主动免疫治疗。比较治疗组与对照组主动免疫治疗效果,观察治疗组主动免疫治疗前后Treg/Th17免疫平衡变化及转化生长因子β1(TGF-β1)、白介素10(IL-10)、白介素(IL-17)水平。结果观察组妊娠成功率86.00%高于对照组25.00%,差异有统计学意义(P<0.05)。结论主动免疫治疗不明原因复发流产可使Treg细胞亚群的数量及功能提高,并使Th17细胞数量及功能降低,提高患者妊娠成功率。
Effect of active immunotherapy on patients with unexplained recurrent miscarriage and its effect on immune balance of Treg / Th17. Methods Seventy patients with unexplained recurrent spontaneous abortion admitted to Zhengzhou Maternal and Child Health Hospital from May 2013 to May 2015 were enrolled in this study. Patients were divided into treatment group (n = 50) and control group (n = 20) according to whether they received active immunotherapy. , The treatment group given active immunotherapy, the control group for various reasons do not agree to take active immunotherapy. The effect of active immunotherapy was compared between the treatment group and the control group. The immune balance of Treg / Th17 and the levels of TGF-β1, IL-10 and IL-17 in the treatment group before and after active immunotherapy were observed. . Results The success rate of pregnancy in observation group was 86.00% higher than that in control group (25.00%), the difference was statistically significant (P <0.05). Conclusions Active immunotherapy for unexplained recurrent miscarriage can increase the number and function of Treg cell subsets and decrease the number and function of Th17 cells and improve the success rate of pregnancy.