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目的:中成药治疗慢性前列腺炎的双盲对照试验报导不多,本文旨在用随机双盲的方法观察前列解毒胶囊治疗慢性前列腺炎的疗效。方法:将慢性前列腺炎患者80例随机分成2组,即前列解毒胶囊+芦氟沙星组(实验组)和安慰剂+芦氟沙星组(对照组),均服药4周。采用双盲对照,所有患者治疗前及治疗4周后均以NIH-CPSI评分、行EPS常规检查。结果:两组患者经治疗4周后,NIH-CPSI总分及疼痛症状评分、排尿症状评分及生活质量评分均比治疗前有显著降低(P<0.05),EPS中WBC计数也明显减少(P<0.05)。实验组治疗后在NIH-CPSI总分、疼痛症状评分、排尿症状评分和生活质量评分方面与对照组相比也有明显改善(P<0.05),但两组治疗后在WBC计数方面无显著性差异(P>0.05)。结论:前列解毒胶囊联合芦氟沙星治疗慢性前列腺炎4周能有效缓解患者疼痛和排尿症状,改善患者生活质量,较单独应用抗生素疗效好。
Objective: Chinese medicine treatment of chronic prostatitis double-blind controlled trial reported little, this paper aims to use randomized double-blind observation of Qianlie Jiedu capsule in the treatment of chronic prostatitis curative effect. Methods: Eighty patients with chronic prostatitis were randomly divided into two groups, namely Qianlie detoxification capsule + rufloxacin group (experimental group) and placebo + rufloxacin group (control group), both for 4 weeks. Double-blind control, all patients before treatment and after 4 weeks of treatment were NIH-CPSI score, routine EPS examination. Results: After 4 weeks treatment, the NIH-CPSI score, pain symptom score, urination symptom score and quality of life score were significantly lower than those before treatment (P <0.05), and the WBC count in EPS was significantly decreased <0.05). The scores of NIH-CPSI score, pain symptom score, voiding symptom score and quality of life score of experimental group were also significantly improved (P <0.05) after treatment, but there was no significant difference in WBC count between the two groups after treatment (P> 0.05). Conclusion: Qianlie Jiedu capsule combined with rufloxacin for chronic prostatitis for 4 weeks can effectively relieve the symptoms of pain and urination and improve the quality of life of patients, which is better than antibiotics alone.