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目的观察瑞舒伐他汀对脑梗死合并动脉粥样硬化患者的神经功能缺损及血清炎症因子的影响。方法选取80例脑梗死患者作为研究对象,按照随机数表法将其分为对照组和实验组,每组40例。对照组采用常规治疗方法,实验组在常规治疗基础上加用瑞舒伐他汀进行治疗,10mg/d,治疗12个月。比较两组患者神经功能缺损改变情况和血清炎症因子的变化。结果治疗后实验组患者颈动脉斑块积分在3、6、12个月逐渐降低,与治疗前比较差异有统计学意义(P<0.05)。治疗后对照组患者的颈动脉斑块积分在3、6、12个月与治疗前比较差异未见统计学意义(P>0.05)。治疗前两组患者的神经功能缺损评分不存在较大的差异,治疗后实验组患者的神经功能缺损评分低于对照组患者,两组之间存在着统计学差异(P<0.05)。治疗后实验组患者的血清hs-CRP、IL-6水平低于对照组患者,两者之间差异明显(P<0.05)。结论瑞舒伐他汀治疗脑梗死,疗效显著,降低神经功能受损,保护神经系统,减小炎症反应,可以在临床中得到较大范围的应用。
Objective To observe the effect of rosuvastatin on neurological deficits and serum inflammatory factors in patients with cerebral infarction and atherosclerosis. Methods Totally 80 patients with cerebral infarction were selected as the research object. According to the random number table, they were divided into control group and experimental group, 40 cases in each group. The control group was treated by routine treatment. The experimental group was treated with rosuvastatin on the basis of conventional treatment, 10mg / d for 12 months. The changes of neurological deficit and serum inflammatory factors in two groups were compared. Results After treatment, carotid plaque score of experimental group decreased gradually at 3, 6 and 12 months, which was significantly different from that before treatment (P <0.05). After treatment, carotid plaque score in control group was no significant difference at 3, 6 and 12 months after treatment (P> 0.05). There was no significant difference in the score of neurological deficit between the two groups before treatment. After treatment, the score of neurological impairment in the experimental group was lower than that of the control group. There was a significant difference between the two groups (P <0.05). After treatment, the levels of serum hs-CRP and IL-6 in the experimental group were lower than those in the control group, with significant difference (P <0.05). Conclusion Rosuvastatin treatment of cerebral infarction, significant effect, reduce nerve function damage, protect the nervous system and reduce the inflammatory response, can be a wide range of clinical applications.