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四环素与环磷酰胺在二甲氧基乙烷存在下反应生成的四环素衍生物(结构式如下)具有抗癌作用,对耶森氏癌和瓦克256肉瘤具有抑制效果,以小白鼠及兔子进行药理试验取得了预期的疗效。
The tetracycline derivatives (structural formula below) produced by the reaction of tetracycline and cyclophosphamide in the presence of dimethoxyethane have anti-cancer effects, inhibitory effect on Jessen’s cancer and WACKER’s 256 sarcoma, and are pharmacologically administered to mice and rabbits Test achieved the desired effect.