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在碘化Ｎ－甲基－２－氯吡啶盐存在下，将４－乙酰基戊酸与四氢噻唑－２－硫酮反应，可获得Ｎ－（４－乙酰基戊酰）．四氢噻唑－２－硫酮，产率５３．８％。将产物Ｉ分别与环己胺、二乙胺、α－苯乙胺进行胺解，得到相应的４－乙酰基酰胺衍生物Ⅱ＿（ａ－ｃ），产率８５％～９４％。
Reaction of 4-acetylvaleric acid with tetrahydrothiazole-2-thione in the presence of N-methyl-2-chloropyridinium iodide gives N- (4-acetylvaleryl). Tetrahydrothiazole-2-thione in 53.8% yield. The product I was amine-catalyzed with cyclohexylamine, diethylamine and α-phenylethylamine respectively to obtain the corresponding 4-acetylamide derivatives Ⅱ_ (a-c) in 85% ~ 94% yield.