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本研究表明，醋酸铅染毒大鼠肝和脑组织中氧自由基的信号随着染毒剂量的增高而增高，表明铅染毒可诱发大鼠体内氧自由基产生；血、肝和脑组织中ＭＤＡ水平升高程度与染毒剂量呈极显著正相关性；红细胞内ＳＯＤ活性下降和ＧＳＨ－Ｐｘ酶活性轻度升高，使得机体清除自由基和抗氧化的能力下降，造成体内的氧自由基蓄积，从而诱发脂质过氧化作用，推测这可能是铅的毒作用机制之一。
The present study showed that the signal of oxygen free radicals in liver and brain tissue of lead-exposed rats increased with the increase of exposure dose, indicating that lead exposure could induce the production of oxygen free radicals in rats and that of blood, liver and brain There was a significant positive correlation between the level of MDA and the exposure dose. The decrease of SOD activity and GSH-Px activity in erythrocytes slightly increased the ability of the body to scavenge free radicals and antioxidants, resulting in the formation of oxygen free radicals Accumulation, which induced lipid peroxidation, speculated that this may be one of the toxic effects of lead.