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目的:研究心理性勃起功能障碍(ED)患者下丘脑代谢的改变,以期为心理性ED可能存在的潜在病因和病理生理机制的探讨提供线索。方法:运用正电子发射断层成像(PET)研究6例心理性ED患者和4例年龄匹配的健康志愿者双侧下丘脑的葡萄糖代谢特点,给予视听性刺激,测定脑组织中18F脱氧葡萄糖(18F-FDG)放射强度,计算单位像素内左(右)丘脑计数/全脑总计数。结果:接受视听性刺激后,健康志愿者双侧下丘脑的18F-FDG代谢明显增高(左:1.026±0.115vs2.400±0.210;右:1.003±0.187vs2.389±0.196;P<0.05),而心理性ED患者双侧下丘脑的18F-FDG代谢变化不明显(左:2.781±0.156vs2.769±0.223;右:2.809±0.129vs2.793±0.217,P>0.05)。结论:心理性ED可能不单纯是功能性疾病,下丘脑可能参与了心理性ED的病理生理过程。
Objective: To study the changes of hypothalamus metabolism in patients with psychic erectile dysfunction (ED) in order to provide clues for the potential etiology and pathophysiological mechanism of psychological ED. Methods: PET was used to study the glucose metabolism characteristics of bilateral hypothalamus in 6 ED patients and 4 age-matched healthy volunteers. Visual acuity stimulation was used to measure 18F-deoxyglucose (18F) in brain tissue -FDG) radiation intensity, calculate left (right) thalamus counts / whole brain totals per unit pixel. RESULTS: After audiovisual stimulation, 18F-FDG metabolism was significantly increased in both hypothalamus of healthy volunteers (left: 1.026 ± 0.115 vs 2.400 ± 0.210; right: 1.003 ± 0.187 vs 2.389 ± 0.196; P <0.05) However, the changes of 18F-FDG metabolism in bilateral hypothalamus of patients with psychic ED were insignificant (left: 2.781 ± 0.156 vs 2769 ± 0.223; right: 2.809 ± 0.129 vs 2.793 ± 0.217, P> 0.05). Conclusions: Psychological ED may not be merely a functional disorder. The hypothalamus may be involved in the pathophysiological process of psychological ED.