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我们对12例肝转移大肠癌患者的外周血、门静脉血、胆汁中癌胚抗原(CEA)的含量进行测定:12例肝转移者,外周血、门静脉血、胆汁中CEA含量分别为16.3ng/ml、24.1ug/ml和302.2ng/ml.对照组8例非肝转移大肠癌,其外周血、门静脉血、胆汁中CEA含量分别为10.9ng/ml、15.2ng/ml和14.8ng/ml.肝转移病人胆汁中CEA含量与肝转移灶的体积大小有密切关系:每1cm~3体积的肝转移灶CEA值为45.8ng/ml.肝转移病人的胆囊胆汁中CEA水平明显高于外周血及门分脉血水平.我们认为通过术前经皮抽取胆囊胆汁标本可以确诊较小的转移灶.同时胆汁CEA测定也可证实CT可疑的肝转移灶.
We measured the levels of carcinoembryonic antigen (CEA) in peripheral blood, portal vein blood, and bile in 12 patients with liver metastases and colorectal cancers. CEA levels in peripheral blood, portal vein blood, and bile in 12 patients with liver metastases were 16.3 ng/well, respectively. Ml, 24.1 ug/ml, and 302.2 ng/ml. Eight non-hepatic metastatic colorectal cancers in the control group had CEA levels of 10.9 ng/ml, 15.2 ng/ml, and 14.8 ng/ml in peripheral blood, portal vein blood, and bile, respectively. The CEA content in bile of patients with hepatic metastasis is closely related to the volume of hepatic metastases: CEA value is 45.8 ng/ml per 1 cm to 3 volumes of liver metastases. CEA levels in gallbladder bile in patients with liver metastases are significantly higher than those in peripheral blood. At the portal vein blood level, we believe that a small metastasis can be diagnosed by preoperative percutaneous extraction of gallbladder bile specimens. Simultaneous bile CEA assay can also confirm CT liver metastasis.