The relationship between the late spring North Atlantic Oscillation (NAO) and the summer extreme precipitation frequency (EPF) in the middle and lower reaches of the Yangtze River Valley (MLYRV) is examined using an NECP/NCAR reanalysis dataset and daily precipitation data from 74 stations in the MLYRV. The results show a significant negative correlation between the May NAO index and the EPF over the MLYRV in the subsequent summer. In positive EPF index years, the East Asian westerly jet shifts farther southward, and two blocking high positive anomalies appear over the Sea of Okhotsk and the Ural Mountains. These anomalies are favorable to the cold air from the mid-high latitudes invading the Yangtze River Valley (YRV). The moisture convergence and the ascending motion dominate the MLYRV. The above patterns are reversed in negative EPF index years. A wave train pattern that originates from the North Atlantic extends eastward to the Mediterranean and then moves to the Tibetan Plateau and from there to the YRV, which is an important link in the May NAO and the summer extreme precipitation in the MLYRV. The wave train may be aroused by the tripole pattern of the SST, which can explain why the May NAO affects the summer EPF in the MLYRV.