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脑性瘫痪是目前导致儿童神经系统严重瘫痪的主要疾病之一,是由多种原因引起的非进行性中枢性运动障碍。目前尚无特殊治疗,多为支持和对症治疗。随着DNA的重组技术和细胞生物学的发展,转基因细胞及细胞系移植已成为脑移植研究新的热点。目前关于细胞移植治疗小儿脑性瘫痪的实验研究主要在新生动物缺氧缺血脑损伤后急性期,所用细胞类型主要是干细胞,且取得了一定的进展。研究发现,干细胞移植入脑内后最长可以存活8个月,并能迁移到损伤区并分化为不同表型的神经细胞可部分改善模型动物的神经行为学障碍。然而干细胞移植后分化为目的神经元的比例较小,这也可能是神经改善不理想的主要原因之一。
Cerebral palsy is one of the major diseases that cause severe paralysis of the nervous system in children at present, and is a non-progressive central movement disorder caused by various reasons. There is no special treatment, mostly for support and symptomatic treatment. With the reorganization of DNA technology and the development of cell biology, transgenic cells and cell lines transplantation has become a new hot spot in brain transplantation. At present, the experimental research on cell transplantation for treatment of cerebral palsy in children is mainly in the acute phase of neonatal hypoxic-ischemic brain damage. The cell types used are mostly stem cells, and some progress has been made. The study found that stem cells migrate into the brain can survive up to 8 months, and can migrate to the damaged area and differentiate into different phenotypes of nerve cells can be partially improved neurological behavioral disorders in model animals. However, the proportion of stem cells that differentiate into neurons of interest after transplantation is small, which may also be one of the major causes of poor neurological amelioration.