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为了研究原发性肝癌对手术之耐受力,自1980至1987年,对358例原发性肝癌术前作γ-谷氨酰转肽酶(γ-GT)活性,血清谷丙转氨酶(SGPT),血清蛋白比值,术中所见肝硬化程度,肿瘤大小,以及各种术式与术后出现肝功能代偿不全的关系作多元回归分析,结果表明:术前γ-GT活性越高,术后肝功能代偿不全发生率越高(P<0.01)。γ-GT活性可作为术前肝手术耐受力的指标,当γ-GT小于40 U％时,基本可作各手术术式;γ-GT>200U％者,结扎肝动脉术要慎重;γ-GT>200U％时,右肝切除术都要慎重;当γ-GT>300u％时,任何术式,即使是剖腹探查,也会出现术后肝功能代偿不全,术后也未能提高病人的生存期。
In order to study the tolerance of primary liver cancer to surgery, from 1983 to 1987, γ-glutamyl transpeptidase (γ-GT) activity and glutamic-pyruvic transaminase (SGPT) were performed in 358 patients with primary liver cancer before surgery. ), The serum protein ratio, the degree of liver cirrhosis seen during surgery, the size of the tumor, and the relationship between various surgical methods and postoperative liver function compensatory incompetence were analyzed by multiple regression analysis. The results showed that the higher the preoperative γ-GT activity, The higher the incidence of compensatory liver function was postoperative (P<0.01). γ-GT activity can be used as an index of preoperative liver surgery tolerance. When γ-GT is less than 40 U%, it can basically be used for each operation; γ-GT>200U%, ligation of the hepatic artery should be careful; -GT>200U%, right hepatectomy should be careful; when γ-GT> 300u%, any surgery, even laparotomy, there will be postoperative liver function insufficiency, postoperative failed to improve The patient’s life span.