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本文报告了我院食管癌、鼻咽癌、肺癌、宫颈癌１７１例患者放疗后免疫功能的变化。观察指标有ＩｇＧ、ＩｇＡ、ＩｇＭ；Ｔ细胞亚群（ＣＤ３、ＣＤ４、ＣＤ８百分比和ＣＤ４／ＣＤ８值）；淋巴细胞转化率。发现放疗后除鼻咽癌ＩｇＡ有明显降低外（Ｐ＜０．０５），其余被测Ｉｇ均无明显降低。淋巴细胞转化率较放疗前明显下降（Ｐ＜０．００１）。总Ｔ细胞百分比无明显降低，ＣＤ４Ｔ细胞明显下降，ＣＤ８Ｔ细胞明显升高。ＣＤ／ＣＤ８值除宫颈癌Ｐ＞０．０５外，其余各组均有明显下降（Ｐ＜０．００１）；放疗后８月，ＣＤ４／ＣＤ８值仍低于放疗前。
This article reports the changes of immune function after radiotherapy in 171 patients with esophageal cancer, nasopharyngeal cancer, lung cancer, and cervical cancer in our hospital. Observed indicators are IgG, IgA, IgM; T cell subsets (CD3, CD4, CD8 percentage, and CD4/CD8 values); Lymphocyte transformation rate. It was found that except IgA of nasopharyngeal carcinoma after radiotherapy was significantly reduced (P<0.05), there was no significant decrease in the other tested Ig. The lymphocyte conversion rate was significantly lower than before radiotherapy (P<0.001). The percentage of total T cells did not decrease significantly, CD4 T cells significantly decreased, and CD8 T cells significantly increased. The CD/CD8 values were significantly lower in the other groups except P>0.05 for cervical cancer (P<0.001); after 8 months of radiotherapy, CD4/CD8 values were still lower than before radiotherapy.