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近20年来,通过内分泌激素与乳腺癌关系的研究,证明一类乳腺癌细胞内含有一种雌激素蛋白质,此物质称雌激素受体。根据生物学特性乳腺癌可分为两类。其中一类乳腺癌,肿瘤生长缓慢,根治切除后预后好,经测定此类乳腺癌细胞内大都含有雌激素受体。另外一类肿瘤生长快,根治切除术后预后差,乳癌细胞内一般无雌激素受体。雌激素受体测定常用饱合活性炭吸附法与组织细胞化学法。这两种方法操作较复杂,存在一定假阳性。最近采用直接放射免疫法。
In the past 20 years, through the study of the relationship between endocrine hormones and breast cancer, it has been demonstrated that a class of breast cancer cells contains an estrogen protein called estrogen receptor. According to biological characteristics breast cancer can be divided into two categories. In one type of breast cancer, the growth of the tumor is slow, and the prognosis after radical resection is good. It is determined that most of these breast cancer cells contain estrogen receptors. Another type of tumor has a rapid growth and has a poor prognosis after radical resection. There is generally no estrogen receptor in breast cancer cells. Estrogen receptor assay is commonly used saturated activated carbon adsorption and histocytochemistry. These two methods are more complicated to operate and have some false positives. Recently, direct radioimmunoassay has been used.