论文部分内容阅读
当今世界,肿瘤已经成为威胁人类健康的重大疾病。在肿瘤疾病中,化疗可控制肿瘤的生长和转移,增强放疗的疗效,是治疗肿瘤疾病的主要手段之一。而肿瘤多药耐药是影响化疗药物疗效、引起化疗失败的重要原因,影响肿瘤患者的治愈效果,降低生存率。如何提高化疗的疗效,延长肿瘤患者的寿命成为医学界的难题。纳米载药系统是生物医学领域研究的热点,相对于单一药物,纳米载药体现了许多优越性,具有良好的应用前景。纳米级颗粒更有利于药代动力学,这些纳米载药颗粒通过被动和主动的机制表现出在全身血液循环寿命延长,持续的药物释放动力,使其能更好的在肿瘤细胞中积累而发挥作用,提高化疗的疗效。本文综述了肿瘤多药耐药研究中主要的纳米载体以及它们在逆转多药耐药方面的应用,并展望载药系统的有更多更好的发展趋势。
In today's world, tumors have become a serious threat to human health. In tumor diseases, chemotherapy can control tumor growth and metastasis and enhance the efficacy of radiation therapy, which is one of the main means of treating tumor diseases. The multidrug resistance of tumor is an important factor that affects the curative effect of chemotherapy drugs and causes the failure of chemotherapy, affects the curative effect of cancer patients and reduces the survival rate. How to improve the curative effect of chemotherapy and prolong the life of cancer patients has become a problem for the medical community. Nanophase drug delivery system is a hot research field in the field of biomedicine. Compared with a single drug, nano drug carrier embodies many advantages and has good application prospects. Nanoparticles are more conducive to pharmacokinetics, the nanoparticles of these nanoparticles through passive and active mechanisms showed an extended life-blood circulation in the body, sustained drug release motivation, so that it can better accumulate in the tumor cells to play Role, improve the efficacy of chemotherapy. This review summarizes the major nanocarriers in multidrug resistance research and their applications in reversing multidrug resistance. It is expected that there will be more and better trends in the development of drug-loaded systems.