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周期节律是由内在时钟系统介导的多重生物过程的周期循环.周期节律系统是由位于大脑的视神经交叉上核的中央时钟系统和位于外周的几乎存在于所有细胞的外周时钟系统组成的.中央时钟与外周时钟都能够对生物体的生理过程进行调控,如激素的分泌、能量代谢、细胞增殖、DNA损伤修复等.而周期节律基因的表达失调,对其下游靶基因包括细胞周期相关基因的表达,以及细胞抗凋亡能力等产生重要的影响.而这一结果会导致细胞增殖加速及基因组不稳定,并可能促进肿瘤的发生.许多实验证据表明,肿瘤是一种节律相关的生理失调,在许多肿瘤中都发现周期节律遭到破坏,如乳腺癌、前列腺癌、子宫内膜癌等.本文将从周期节律对细胞周期进程及对细胞DNA损伤修复的影响来讨论分子水平上细胞的周期节律与肿瘤发生发展的关系.
Periodic rhythms are periodic cycles of multiple biological processes mediated by an internal clock system that is composed of a central clock system located at the suprachiasmatic nucleus of the brain and a peripheral clock system located almost peripherally to all cells. Both the clock and the peripheral clock can regulate the physiological process of the organism, such as secretion of hormones, energy metabolism, cell proliferation, DNA damage repair, etc. The expression of the circadian rhythm gene is imbalanced, and its downstream target genes, including the cell cycle related genes Expression and cell anti-apoptotic ability have a significant impact, and this result will lead to accelerated cell proliferation and genomic instability, and may promote the occurrence of tumors.Many experimental evidence that the tumor is a rhythm-related physiological disorders, Circulatory rhythms have been found in many tumors, such as breast cancer, prostate cancer, endometrial cancer, etc. This article discusses the cell cycle at the molecular level from the effects of circadian rhythms on cell cycle progression and on the repair of cellular DNA damage Rhythm and tumor development.