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胃癌是常见的恶性肿瘤之一,在我国其发病率居各类肿瘤前列,导致的死亡人数占所有肿瘤的四分之一,而且每年有近40万新增的胃癌病人,但是其早期诊断率低于20%,胃癌已经成为危害人民健康的最严重的疾病之一。白细胞介素(interleukin,IL)作为在白细胞或免疫细胞间相互作用的淋巴因子,不仅在介导T、B细胞活化、增殖与分化以及炎症反应中起着重要作用,近年来,越来越多的学者发现其与肿瘤的发生及发展也有着密不可分的联系。目前为止,已经发现了29种白细胞介素,分别被命名为IL-1~IL-29,它们各自承担着相应的使命。国内外大量实验及文献表明,IL-1,IL-6,IL-8和胃癌有着密切的关系,这对于胃癌的早期诊断及治疗提出了新的思路,进而提高胃癌的早期诊断率,改善胃癌的治疗状况。本文对IL-1,IL-6,IL-8的来源、分子结构及受体方面进行简要概述,同时阐述了其生物学特性及与胃癌的关系。
Gastric cancer is one of the common malignant tumors. The incidence of gastric cancer in our country ranks forefront in all kinds of tumors, causing the death toll accounting for one-fourth of all tumors, and nearly 400,000 new gastric cancer patients annually, but its early diagnosis rate Below 20%, gastric cancer has become one of the most serious diseases that endanger people’s health. Interleukin (IL), as a lymphokine that interacts with leukocytes or immune cells, plays an important role not only in mediating T, B cell activation, proliferation and differentiation, and inflammatory response. In recent years, more and more Scholars have found that it is also inextricably linked with the occurrence and development of tumors. So far, 29 kinds of interleukins have been found, named as IL-1 ~ IL-29, and each of them has the corresponding mission. A large number of domestic and foreign experiments and literature show that IL-1, IL-6, IL-8 and gastric cancer are closely related, which for the early diagnosis and treatment of gastric cancer put forward new ideas, thereby increasing the early diagnosis of gastric cancer and improve gastric cancer The treatment status. This article gives a brief overview of the sources, molecular structures and receptors of IL-1, IL-6 and IL-8, as well as its biological characteristics and its relationship with gastric cancer.