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目的探讨护骨素(OPG)和可溶性核因子кB受体活化因子配体(sRANKL)在非小细胞肺癌(NSCLC)诊断和鉴别诊断中的意义。方法分别选取50例NSCLC患者、25例肺部良性占位患者和25例正常体检者,采用酶联免疫吸附法检测患者中血清OPG和sRANKL的水平。结果NSCLC组的sRANKL水平和sRANKL/OPG比值均高于良性占位组和正常体检组(P<0.05);三组间OPG水平比较,差异无统计学意义(P>0.05)。血清sRANKL和sRANKL/OPG比值诊断NSCLC的最佳截断点分别为>4.20 pmol/L和>0.60,sRANKL诊断的敏感度、特异度和准确性分别为74.0%、84.0%和77.3%,sRANKL/OPG比值诊断的敏感度、特异度和准确性分别为84.0%、88.0%和85.3%。血清sRANKL和sRANKL/OPG比值鉴别诊断肺部良恶性占位病变的最佳截断点分别为>5.24 pmol/L和>0.63,sRANKL鉴别诊断的敏感度、特异度和准确性分别为60.0%、84.0%和68.0%,sRANKL/OPG比值诊断的敏感度、特异度和准确性分别为78.0%、64.0%和73.3%。结论血清sRANKL水平和sRANKL/OPG比值可作为NSCLC的辅助诊断指标。
Objective To investigate the significance of osteoprotegerin (OPG) and soluble nuclear factor kappa B receptor activator ligand (sRANKL) in the diagnosis and differential diagnosis of non-small cell lung cancer (NSCLC). Methods Fifty patients with NSCLC, 25 patients with benign lungs and 25 normal controls were enrolled in this study. Serum levels of OPG and sRANKL were detected by enzyme-linked immunosorbent assay (ELISA). Results The levels of sRANKL and sRANKL / OPG in NSCLC group were significantly higher than those in benign and normal subjects (P <0.05). There was no significant difference in OPG levels between the three groups (P> 0.05). The best cutoff points of serum sRANKL and sRANKL / OPG in diagnosing NSCLC were> 4.20 pmol / L and> 0.60, respectively. The sensitivity, specificity and accuracy of sRANKL in diagnosing NSCLC were 74.0%, 84.0% and 77.3% The sensitivity, specificity and accuracy of ratio diagnosis were 84.0%, 88.0% and 85.3%, respectively. The best cutoff points of serum sRANKL and sRANKL / OPG in the differential diagnosis of benign and malignant lung lesions were> 5.24 pmol / L and> 0.63 respectively. The sensitivity, specificity and accuracy of sRANKL in differential diagnosis were 60.0%, 84.0 % And 68.0%. The sensitivity, specificity and accuracy of sRANKL / OPG were 78.0%, 64.0% and 73.3% respectively. Conclusion Serum sRANKL levels and sRANKL / OPG ratio can be used as auxiliary diagnostic indicators of NSCLC.