目的观察马拉硫磷对小鼠肾脏的毒性作用。方法分别采用高、中、低剂量的马拉硫磷静式吸入染毒小鼠,染毒后90d剖检,切取肾组织制片、HE染色,进行形态学观察。结果马拉硫磷染毒小鼠肾组织出现不同程度的损伤,特别是高剂量组,肾小管上皮细胞变性、坏死,间质充血、炎细胞浸润以及肉芽肿样病变、纤维组织增生等。结论静式吸入马拉硫磷导致小鼠中毒性肾病。 Objective To observe the toxic effects of malathion on the kidneys of mice. Methods Mild, medium and low doses of malathion were inhaled intravenously. The mice were necropsied 90 days after the infection. The kidneys were sectioned and stained with HE for morphological observation. Results Malathion-treated mice showed different degrees of renal injury, especially in the high-dose group. Renal tubular epithelial cells were degenerated, necrotic, interstitial hyperemia, inflammatory cell infiltration and granulomatous lesions and fibrous tissue hyperplasia. Conclusion Inhaled malathion lead to toxic nephropathy in mice.