目的:分析北京医院喹诺酮类抗菌药引起的不良反应发生情况及临床表现,为临床合理使用提供依据。方法:回顾性地对2003～2007年我院上报的128例喹诺酮类药不良反应报告按患者性别、年龄,药物种类、给药途径,涉及器官或系统,不良反应的临床表现进行统计、分析。结果:涉及不良反应的喹诺酮类药品共有7种,以左旋氧氟沙星居首位,用药途径以静脉给药为主,主要的不良反应类型为皮肤损害。结论:应继续加强抗感染药不良反应监测,以促进临床合理用药,保证患者用药安全。 Objective: To analyze the incidence and clinical manifestations of quinolone antibiotics-induced adverse reactions in Beijing Hospital and provide the basis for clinical rational use. Methods: Retrospectively, 128 cases of quinolone adverse reactions reported in our hospital from 2003 to 2007 were analyzed and statistically analyzed according to their gender, age, drug type, route of administration, organ or system involved, adverse reactions. Results: There were 7 quinolones involved in adverse reactions, with levofloxacin ranking the top. The main route of administration was intravenous administration, and the main adverse reaction type was skin damage. Conclusion: Adverse reaction monitoring of anti-infectives should be continuously strengthened to promote rational drug use in clinical practice and ensure the safety of patients.