INTRODUCTIONrnThe skeleton, accounting for approximately 15％ of total human body weight, is one of our largest organ systems in the human body. It has traditionally been considered as a structural organ that provides mechanical support for stature and locomotion in addition to providing protection for vital organs. Bone is also an important reservoir for a number of minerals including calcium, phosphate, magnesium and organic molecules including collagen fibers and amorphous matrix.