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采用一次性尾静脉注射阿霉素7mg／kg制备大白鼠肾病模型。分为注射后一周、二周、四周三组，同时设立正常对照组，分别测定各组肾皮髓质、血清超氧化物歧化酶（SOD）活性和丙二醛（MDA）水平。结果肾病组肾组织、血清SOD活性和MDA水平明显高于对照组血清SOD／MDA比值明显低于对照组，四周组也明显低于一周和二周组。24小时尿蛋白排泄、血肌酐与肾组织MDA、血清MDA水平呈正相关，与血清SOD／MDA呈负相关，说明脂质过氧化反应参与阿霉素肾病的发病。
A one-time tail vein injection of doxorubicin 7mg / kg rat model of kidney disease. The rats were divided into three groups: one week, two weeks and four weeks after injection. At the same time, a normal control group was established. The activities of renal cortex, serum superoxide dismutase (SOD) and malondialdehyde (MDA) were measured. Results The renal SOD activity and MDA level in renal tissue were significantly higher than those in the control group, and the serum SOD / MDA ratio in the nephropathy group was significantly lower than that in the control group. The four weeks group was also significantly lower than the one week and two weeks group. 24-hour urine protein excretion, serum creatinine and renal tissue MDA, serum MDA levels were positively correlated with serum SOD / MDA was negatively correlated, indicating lipid peroxidation involved in the pathogenesis of doxorubicin nephropathy.