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目的研究盐酸氨溴索联合N-乙酰半胱氨酸治疗慢性支气管炎的临床疗效。方法研究纳入98例确诊的慢性支气管炎患者,其中男性75例,女性23例。将患者随机分为单纯盐酸氨溴索治疗的对照组(49例)和联合了N-乙酰半胱氨酸治疗的观察组(49例)。此外,两组均给予抗炎等常规治疗。按上述方案治疗6个月后,比较两组的治疗效果,用力肺活量(FVC)、FEV1/预计值(%)、FEV1/FVC(%)等肺功能指标以及生活质量评分在治疗前后的改变。结果两组均能在消除咳嗽、咳痰、喘息等症状方面取得良好疗效,在影像学检查指标方面也均达到预期的治疗效果。但联合N-乙酰半胱氨酸治疗的观察组总体有效率更高,与对照组相比差异具有统计学意义(P<0.05),此外观察组患者的肺功能指标在治疗后优于对照组(P<0.05),生活质量评分也高于对照组(P<0.05)。结论盐酸氨溴索联合N-乙酰半胱氨酸治疗慢性支气管炎的临床疗效较优,可以在临床中推广。
Objective To study the clinical efficacy of ambroxol hydrochloride combined with N-acetylcysteine in the treatment of chronic bronchitis. Methods The study included 98 patients with chronic bronchitis diagnosed, including 75 males and 23 females. The patients were randomly divided into control group (49 cases) treated with ambroxol hydrochloride alone and observation group (49 cases) treated with N-acetylcysteine. In addition, both groups were given anti-inflammatory and other conventional treatment. After 6 months of treatment according to the above protocol, the lung function indexes such as therapeutic effect, forced vital capacity (FVC), FEV1 / predicted value (%), FEV1 / FVC (%) and quality of life score were compared before and after treatment. Results Both groups achieved good results in relieving the symptoms such as cough, expectoration and wheezing, and achieved the expected therapeutic effect in imaging examination indexes. However, the observation group treated with N-acetylcysteine was generally more effective, with statistical significance compared with the control group (P <0.05). In addition, the lung function of the observation group was better than that of the control group (P <0.05), and the quality of life score was also higher than that of the control group (P <0.05). Conclusion Ambroxol hydrochloride combined with N-acetylcysteine has better clinical efficacy in the treatment of chronic bronchitis and can be widely used in clinical practice.