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GS-164是一新型小分子化合物,它通过与紫杉醇相似的作用机理,刺激微管蛋白的聚合。在体外微管聚合分析发现GS-164具有以下作用特点:(1)在无三磷酸鸟苷(GTP)情况下,GS-164导致的微管聚合具有剂量依赖关系;(2)由此药刺激形成的微管能抵抗由钙和低温导致的分离;(3)鬼臼毒素对由GS-
GS-164 is a novel small molecule compound that stimulates tubulin polymerization through a similar mechanism of action to paclitaxel. In vitro microtubule polymerization analysis revealed that GS-164 has the following features: (1) microtubule polymerization induced by GS-164 in a dose-dependent manner in the absence of guanosine triphosphate (GTP); (2) The formation of microtubules can resist the separation caused by calcium and low temperature; (3) podophyllotoxin by GS-