近年来已报道了麻风杆菌在试管内单独或细胞内培养时能摄入各种放射标记化合物。这些试验(持续1～2周)能精确地测定麻风杆菌的生活力并且具有筛选抗麻风药物和诊断麻风耐药的潜力。作者实验室已经建立了试管中的快速的巨噬细胞内麻风杆菌放射标记法来测定麻风杆菌的活力和对氨苯砜、利福平及淋巴因子的敏感性,并且证明了7株疑似耐药的麻风菌试管内结果和鼠足垫结果完全一致。为了进一步评定这种放射测定法,在三个独立的中心 In recent years, it has been reported that M. leprae can ingest various radiolabeled compounds when cultured in vitro alone or in a cell. These tests (lasting 1 to 2 weeks) accurately measure the viability of leprosy and have the potential to screen anti-leprosy drugs and diagnose leprosy. The authors laboratory has established rapid macrophage-mediated detection of M. leprae in test tubes to determine the activity of leprosy and susceptibility to dapsone, rifampicin and lymphokines, and has demonstrated that seven suspected resistance The results of the leprosy test tube and the rat footpad are exactly the same. To further assess this radiometric method, three independent centers were used