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近年证明铂化合物有显著抗瘤作用,在临床肿瘤化疗上有重要位置。我们曾研究过国产顺氯氨铂的药理作用。为了寻找新的抗瘤有效铂化物,我们研究了4种新的四价铂化合物,其中如二羟基-丙二酸根-二氨合铂[Pt(NH)_2(mal)(OH)_2]等,均证明对大鼠W256癌肉瘤有明显的抗瘤作用。后又继续研究,分别在大鼠测定各药的半数致死量(LD50),
In recent years, it has been demonstrated that platinum compounds have significant anti-tumor effects and play an important role in clinical cancer chemotherapy. We have studied the pharmacological effects of domestic cisplatin. In order to find new anti-tumor effective platinum compounds, we studied four new tetravalent platinum compounds, such as dihydroxy-malonate-diammine platinum [Pt(NH)_2(mal)(OH)_2] etc. All proved to have a significant anti-tumor effect on rat W256 carcinosarcoma. After the study was continued, the median lethal dose (LD50) of each drug was determined in rats.