癌调蛋白[Oncomodulin]是 MacManus1979年发现的。这种肿瘤细胞特有的钙调蛋白广泛分布于人类膀胱、乳腺、结肠、喉、肝、肺、皮肤、舌、子宫颈肿瘤和啮齿类动物的肿瘤。据报道在肾上腺、膀胱、脑、膈、脂肪组织、小肠、大肠、肾、肝、淋巴结、骨骼肌、卵巢、前列腺、甲状腺、腮腺、皮肤、肾、睾丸、胸腺和子宫等正常组织,胚胎组织及肿瘤周围组织中均未能检出.现在,MacManus 报道利用抗生物素蛋白(生物素)过氧化物酶免疫组织化学技术在胎盘中找到了癌调蛋白,并得到了胎盘癌调蛋白的纯品,经氨基酸分析和高效液相色谱分析证实与肿瘤组织中的癌调蛋白相同.作者一直在研究能否把癌调蛋白作为一种标志物用于肿瘤诊断.(参看本刊1985年第5期综述:钙调 Oncomodulin was discovered in 1979 by MacManus. The calmodulin unique to this tumor cell is widely distributed in human bladder, breast, colon, larynx, liver, lung, skin, tongue, cervix tumors and rodent tumors. According to reports in the adrenal, bladder, brain, iliac crest, adipose tissue, small intestine, large intestine, kidney, liver, lymph nodes, skeletal muscle, ovary, prostate, thyroid gland, parotid gland, skin, kidney, testis, thymus and uterus and other normal tissues, embryonic tissue In and around the tumor tissue were not detected. Now, MacManus reported using avidin (biotin) peroxidase immunohistochemical technique to find the tunein in the placenta and obtained the placental cancer protein pure The product was confirmed by amino acid analysis and high performance liquid chromatography to be identical to that of tumourin in tumor tissues. The authors have been investigating the possibility of using tunica tocopherol as a marker for tumour diagnosis. (See our article 5 of 1985) Review: Calcium