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目的分析2013—2015年东阳市疑似预防接种异常反应(AEFI)发生的特征,评价AEFI监测工作开展情况。方法通过国家AEFI信息监测系统收集东阳市2013—2015年报告的AEFI个案数据,按年份、AEFI分类、疫苗种类计算AEFI发生率,并分析AEFI发生的时间分布、地区分布和人群分布特征。结果 2013—2015年东阳市共报告AEFI 136例,各年报告发生率分别为6.29/10万、10.87/10万、12.54/10万,累计报告发生率为10.08/10万;涉及21种疫苗,报告发生率最高的3种疫苗分别为五联疫苗(102.77/10万)、23价肺炎疫苗(52.82/10万)、白破疫苗(26.27/10万);一般反应104例,主要为发热/红肿/硬结,占96.15%;异常反应25例,主要为过敏性皮疹,占64.00%;偶合症7例。全市18个乡镇AEFI报告当年覆盖乡镇数分别为12、16和18个,报告发生率前三位的乡镇分别是东江镇(38.36/10万)、佐村镇(22.43/10万)、三单乡(19.01/10万)。AEFI发生在接种后0~1 d 119例,占87.50%;AEFI报告主要集中在3—9月,占74.26%;发生年龄集中在<1岁,占41.18%。结论东阳市2013—2015年AEFI监测敏感性有所提高,AEFI常发生于年龄较小儿童和接种后≤1 d,需进一步加强AEFI监测工作。
Objective To analyze the characteristics of suspected AEFI occurrence in Dongyang from 2013 to 2015 and evaluate the progress of AEFI surveillance. Methods The AEFI data collected from Dongyang in 2013-2015 were collected through national AEFI information monitoring system. The incidence of AEFI was calculated by year, AEFI classification and type of vaccine, and the distribution of time, distribution and population distribution of AEFI were analyzed. Results A total of 136 AEFI cases were reported in Dongyang City from 2013 to 2015, with a reported incidence of 6.29 / lakh, 10.87 / lakh and 12.54 / lakh, respectively, with a cumulative reporting rate of 10.08 / lakh. The reported 21 vaccines, The three vaccines with the highest reported incidence were five vaccines (102.77 / 100000), 23 pneumococcal vaccines (52.82 / 100000) and white broken vaccines (26.27 / 100000) respectively. The general response was 104 cases, mainly fever / Swelling and sclerosis, accounting for 96.15%; 25 cases of abnormal reaction, mainly allergic rash, accounting for 64.00%; 7 cases of coupling syndrome. The AEFI reports of the 18 townships in the city at that time covered 12, 16 and 18 townships respectively. The top three towns in the report area were Dongjiang Town (38.36 / 100000), Zacun Town (22.43 / 100000), Sanyang Township (19.01 / 100,000). AEFI occurred 119 cases (0 ~ 1 days) after vaccination, accounting for 87.50%. The AEFI report mainly concentrated in the period from March to September, accounting for 74.26%. The age of onset was <1 year, accounting for 41.18%. Conclusion The sensitivity of AEFI monitoring in 2013-2015 in Dongyang City was improved. AEFI often occurs in younger children and ≤1 days after inoculation. It is necessary to further strengthen the monitoring of AEFI.