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目的:观察大剂量维生素B12联合针刺治疗三叉神经痛的临床疗效及其副作用。方法:选取三叉神经痛患者86例,随机分为观察组及对照组各43例,观察组采取大剂量维生素B12联合针刺治疗,对照组用维生素B12联合卡马西平治疗,观察患者临床疗效及治疗期间药物副作用发生情况。结果:观察组治愈率32.56%,显效率53.49%,对照组分别为18.61%、34.89%,两组比较无显著性差异(P>0.05);总有效率观察组97.67%,对照组为74.42%,存在显著性差异(P<0.05);观察组药物副作用发生率6.98%,对照组60.47%,存在显著性差异(P<0.05)。结论:大剂量维生素B12联合针刺治疗三叉神经痛临床疗效满意,优于单纯药物治疗,不良反应发生率低,值得临床推广应用。
Objective: To observe the clinical efficacy and side effects of high-dose vitamin B12 combined with acupuncture in the treatment of trigeminal neuralgia. Methods: Eighty-six patients with trigeminal neuralgia were randomly divided into observation group and control group, 43 cases in each group. The observation group was treated with high-dose vitamin B12 and acupuncture. The control group was treated with vitamin B12 and carbamazepine. The clinical efficacy and Drug side effects during treatment. Results: The cure rate of observation group was 32.56%, the effective rate was 53.49%, the control group was 18.61% and 34.89% respectively, there was no significant difference between two groups (P> 0.05); the total effective rate was 97.67% in observation group and 74.42% (P <0.05). The incidence of side effects in the observation group was 6.98% and in the control group was 60.47%, there was a significant difference (P <0.05). Conclusion: The high dose of vitamin B12 combined with acupuncture treatment of trigeminal neuralgia clinical efficacy is better than simple drug treatment, the incidence of adverse reactions is low, worthy of clinical application.