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目的探讨原发性肺癌患者血清抗利尿激素(ADH)、肿瘤坏死因子α(TNF-α)水平与其预后的相关性。方法随机选取2008年1月至2010年1月期间廉江市人民医院收治的原发性肺癌需行手术切除患者44例作为观察组,另选取30例同期健康体检者作为对照。分别采用放射免疫法和ELISA法检测两组血清ADH、TNF-α水平。观察组均接受手术切除治疗并于术后1d、3d、5d、7d、10d和14d时复查以上项目。统计患者无疾病进展生存期(DFS)和5年生存率并分析患者血清ADH、TNF-α水平与其DFS及5年生存率的关系。结果观察组术前血清ADH、TNF-α水平均高于对照组,观察组术后5d、7d、10d和14d的血清ADH、TNF-α水平则均低于其术前,差异有统计学意义(P<0.05)。观察组平均DFS为(8.26±1.15)月,5年生存率22.73%。Pearson相关性分析结果显示,原发性肺癌患者血清ADH、TNF-α水平与其DFS均呈负相关(r=-0.743,-0.772)。Spearman秩相关分析结果显示,原发性肺癌患者血清ADH、TNF-α水平与其5年生存率均呈负相关(r=-0.726,-0.753)。结论原发性肺癌患者血清ADH、TNF-α水平较高且均与其DFS和5年生存率负相关,因此血清ADH、TNF-α可作为原发性肺癌患者预后评估及治疗方案制定的参考依据。
Objective To investigate the correlation between serum levels of anti-diuretic hormone (ADH) and tumor necrosis factor-α (TNF-α) in patients with primary lung cancer and its prognosis. Methods Forty-four patients with primary lung cancer admitted to Lianjiang Municipal People’s Hospital from January 2008 to January 2010 were randomly selected as the observation group and 30 healthy controls were selected as controls. The serum levels of ADH and TNF-α were detected by radioimmunoassay and ELISA respectively. The observation group received surgical resection and the above items were reviewed on the 1st, 3rd, 5th, 7th, 10th and 14th day postoperatively. The patients with no disease progression-free survival (DFS) and 5-year survival rates were analyzed and the relationship between serum ADH, TNF-α and their DFS and 5-year survival rate were analyzed. Results The serum levels of ADH and TNF-α in the observation group before operation were significantly higher than those in the control group. The levels of serum ADH and TNF-α in the observation group at 5d, 7d, 10d and 14d after operation were lower than those before operation (P <0.05). The average DFS in the observation group was (8.26 ± 1.15) months, and the 5-year survival rate was 22.73%. Pearson correlation analysis showed that serum ADH and TNF-α levels in patients with primary lung cancer were negatively correlated with their DFS (r = -0.743, -0.772). Spearman rank correlation analysis showed that serum ADH and TNF-α levels in patients with primary lung cancer were negatively correlated with their 5-year survival rates (r = -0.726, -0.753). Conclusions Serum levels of ADH and TNF-α in patients with primary lung cancer are higher than those in patients with primary lung cancer, and both of them are negatively correlated with their DFS and 5-year survival rate. Therefore, serum ADH and TNF-α may serve as reference for prognosis evaluation and treatment planning of patients with primary lung cancer .