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目的分析咸阳市HIV抗体不确定结果的特征、产生的原因和对艾滋病防控工作的影响。方法对2010-2016年咸阳市艾滋病确证实验室免疫印迹试验方法检测发现的112例HIV抗体不确定病例及随访的54例进行描述,并采用卡方检验对结果进行分析。结果 112例不确定病例中,无偿献血占59.82%(67/112)、医院病人占31.25%(35/112)、自愿咨询检测(VCT)人群占8.92%(10/112)。不同人群的不确定病例阳转率差异无统计学意义(χ~2=4.370,P>0.05)。不确定条带有7种带型,其中构成比排在前3位的分别是p24、gp160和gp160,p24占不确定样本总数的88.39%。54例完成随访检测,占48.21%(54/112)。其中35例转阴条带类型中以p24带型为主;12例转阳带型中Env类条带不确定的占84.21%(16/19)。结论加强不确定病例的随访,提高受检者HIV抗体诊断效率,做到尽早诊断、尽早治疗。
Objective To analyze the characteristics, causes and impact of HIV antibody uncertainties in Xianyang City. Methods 112 cases of HIV antibody indeterminate cases and 54 cases of follow-up were detected in 2010-2016 AIDS confirmed laboratory immunoblot test in Xianyang City, and the results were analyzed by chi-square test. Results Of the 112 cases of indeterminate cases, 59.82% (67/112) were unpaid blood donors, 31.25% (35/112) were hospital patients and 8.92% (10/112) were patients with voluntary counseling and testing (VCT). There was no statistically significant difference in the positive rate of cases in different population (χ ~ 2 = 4.370, P> 0.05). There are 7 bands in the indeterminate bands, of which p24, gp160 and gp160 constitute the first three bands respectively, p24 occupy 88.39% of the total number of indefinite samples. 54 cases completed follow-up testing, accounting for 48.21% (54/112). Among 35 cases, the type of negative vaginal band was predominantly p24 band, while the positive band of Env in 12 cases was 84.21% (16/19). Conclusion To strengthen the follow-up of uncertain cases and improve the diagnostic efficiency of HIV antibody in subjects so that they can be diagnosed as soon as possible and treated as soon as possible.