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我们曾报导在DAB诱发大鼠肝癌的早期（2～4周）,肝细胞核和细胞质RNA的杂交竞争抑制能力增强,到晚期则比早期减弱,显示DAB诱癌的整个过程鼠肝RNA的复杂性有不同程度的改变。Britten等应用DNA复性动力学的方法,将真核生物的DNA分为单一顺序,中度重复顺序和高度重复顺序三种不同的基因组织。单一顺序DNA属结构基因,隐藏着巨大的遗传信息,由此种顺序拷贝各种功能蛋白质。中度重复顺序DNA,有
We have reported that at the early stage of DAB-induced liver cancer in rats (2 to 4 weeks), the competitive inhibition of hepatocellular nuclear and cytoplasmic RNAs is enhanced, and it is attenuated earlier than late, indicating the complexity of RNAi in the liver during the entire DAB-induced cancer process. There are varying degrees of change. Britten et al. used the method of DNA renaturation kinetics to classify eukaryotic DNA into three different gene organizations: a single sequence, a moderately repeated sequence, and a highly repeated sequence. A single sequence of DNA is a structural gene that hides huge genetic information and copies various functional proteins in this order. Moderate repeat sequence DNA, with