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本文分析了10例正常人和88例上消化道疾病患者胃粘液-碳酸氢盐屏障功能,证实其在正常情况下有中和胃酸、减弱胃蛋白酶活性的作用。球溃患者中和指数和粘液保护指数明显低于正常,可能是伴发胃部病变的一个原因,胃部疾病患者HCO_3~-和酸性粘蛋白减少是病变损伤上皮细胞的继发结果,胃溃患者中性粘蛋白升高可能与胆汁返流加速可见性粘液分解有关,某些药物对HCO_3~-分泌可能有促进作用。
This article analyzed gastric mucosa-bicarbonate barrier function in 10 normal subjects and 88 patients with upper digestive tract disease, confirming that it can neutralize gastric acid and weaken pepsin activity under normal conditions. Neutralization index and mucus protection index in patients with balloon collapse are significantly lower than normal, which may be a cause of gastric lesions. The decrease of HCO_3~- and acid mucin in gastric diseases is secondary to the lesioned epithelial cells. The increase in patients with neutropenia may be related to bile reflux accelerating visible viscous degeneration, and some drugs may contribute to HCO_3~-secretion.