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辐射对组织的非随机效应可用组织反应的靶细胞学说来解释。该学说为阐明损伤而出现时间与剂量反应关系方面的差异提供了理论基础。骨髓的反应是等级型组织反应的一个实例,人骨髓的LD_(50)估计在2～5Gy之间(骨髓剂量)。肺是灵活型组织的实例之一,人肺的LD_(50)约为9.5Gy(肺剂量)。组织残留损伤的机制可用靶细胞群衰竭来解释。
The non-random effect of radiation on tissue can be explained by the theory of target cells in tissue response. The theory provides a theoretical basis for clarifying the differences in the time of emergence and dose-response relationship. The bone marrow response is an example of a graded tissue reaction. The LD_(50) of human bone marrow is estimated to be between 2 and 5 Gy (the bone marrow dose). The lung is an example of a flexible tissue, and the LD_(50) of human lung is about 9.5 Gy (lung dose). The mechanism of tissue residual damage can be explained by the failure of the target cell population.